3D Bioprinting for Wound Care Products

Bioprinting is an emerging technology that can spatially control the process of engineering tissues with different materials and cell types, which can be used for either therapeutic purposes or artificial tissue models for drug test and discovery. Further, it can be used to explore new knowledge of cell-material interactions in a wide range of physical dimensions and biological scales, from molecular to cellular to tissue. This wound care research is focused on creating biomimetic tissue constructs containing multiple biomaterials in bioinks. We have developed bioactive wound dressings with promising in vitro and in vivo results. Our research group not only investigates the fundamental scientific issues such as cell interactions with micro and nano environments, characterization of bioinks, and biomechanics, but also solves the technological and translational issues associated with tissue repair and regeneration. We focus on vascularized tissue repair and regeneration by controlling the external geometry, microarchitecture, and chemical structure. The highly customizable CellInk Inkredible+ and Bio-X bioprinters available in our laboratory enable us to work with a variety of materials including gelatin, GelMa, alginate, chitosan, PLA, PCL, and bioactive glass in different scaffolds and other geometries.